2015 Trumbull Memorial Hospital Demo

Diphenhydramine (Benadryl) Diphenhydramine (Benadryl ® )

Action

Onset

Antihistamine

Onset < 15 min Peak effect 1-4 hours

Indications Allergic Reaction (Localized and Systemic) (Adult and Pediatric) Extrapyramidal Side Effects

Adult Dose 25-50 mg slow IV/IO, or IM, repeat 25 mg after 10 minutes if no response (Max 50 mg total)

Pediatric Dose 1 mg/kg slow IV/IO, or IM, maximum 25 mg

Contraindications Hypersensitivity, nursing mothers (unless life threatening reaction)

Adverse Reactions Cardiovascular: Hypotension, headache, palpitations, tachycardia, premature heart contractions CNS: Sedation, sleepiness, dizziness, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, blurred vision, vertigo, tinnitus, convulsions Gastrointestinal: Nausea, vomiting, diarrhea Respiratory: Thickening of bronchial secretions, tightness of chest and wheezing, nasal congestion Precautions Has atropine-like action and should be used with caution in patients with a history of bronchial asthma, increased intraocular pressure, cardiovascular disease, or hypertension. Use caution with lower respiratory disease, including asthma.

Considerations Promethazine (Phenergan), Haldol, and Reglan may cause extrapyramidal side effects.

198

EMR

EMT

AEMT

Paramedic

Extended